Screening INR deviation of local prothrombin time systems
نویسندگان
چکیده
منابع مشابه
Screening INR deviation of local prothrombin time systems.
AIM To assess the reliability of local international normalised ratios (INR) using a set of three international reference preparation (IRP) certified freeze dried plasmas. METHODS 55 centres in the United Kingdom and the Republic of Ireland participated; 36 centres employed coagulometers and 19 a manual prothrombin time technique, all with the same batch of routine commercial thromboplastin. ...
متن کاملA New Generation Prothrombin Time Method for INR
Prothrombin time (PT) is the leading test for monitoring oral anticoagulation therapy (OAT). We sought to determine INR taking into account only active coagulation factors FII, FVII and FX without inhibition in patient plasmas and calibrator kits.We measured PT using a combined thromboplastin reagent. The calculation was based on a new PT method, which measures active coagulation factors (F II,...
متن کاملINR calibration of Owren-type prothrombin time based on the relationship between PT% and INR utilizing normal plasma samples.
Prothrombin time (PT) is clinically important and is used to monitor oral anticoagulant therapy. To obtain PT results in international normalized ratio (INR), the current standardization procedure is complex and involves reference reagents. The PT of diluted plasma samples can be determined with a combined thromboplastin (the Owren-type procedure), but not necessarily with a plain thromboplasti...
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BACKGROUND The need to perform local International Sensitivity Index (ISI) calibrations and in particular the requirement for a manual method for prothrombin time (PT) determination, have proved to be obstacles to application of the WHO scheme for PT standardization. METHODS We used international normalized ratio (INR) derived with a set of only 5 European Concerted Action on Anticoagulation ...
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Oral anticoagulant therapy (OAT) using warfarin (Coumadin®) has surged in recent years due to an increased number of indications and its demonstrated effectiveness.1 The primary means of monitoring the response to warfarin is the Prothrombin Time (PT) test, which is measured in seconds.2,3 The increased use of OAT has led to the development of point-of-care (POC) portable monitoring devices des...
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ژورنال
عنوان ژورنال: Journal of Clinical Pathology
سال: 1998
ISSN: 0021-9746
DOI: 10.1136/jcp.51.5.356